Explore our platform capabilities

De novo protein design and variant effect prediction

Web app tutorials

• Prompt and prompt sampling methods
• PoET scoring and log-likelihood
• Rank Sequences tool
• PoET Substitution Analysis tool
• Generate Sequences tool

Python API tutorials

• Creating an MSA
• Creating a prompt
• Scoring sequences
• Single site analysis
• Generating sequences

Walkthroughs

• Web app: Finding mutational hotspots and designing one-shot variant libraries
• Python API: Predicting the fitness of isomerases without experimental data
• Python API: Understanding the impact of substitution and deletions on aliphatic amidase using different large language models
• Python API: Screening insertion locations with PoET

Function prediction and optimization with your data

Web app tutorials

• Uploading your data
• OP Models scoring and log-likelihood
• Visualization
• Model training and evaluation
• Substitution analysis with OP Models
• Design

Python API tutorials

• Uploading data
• Training models
• Designing sequences
• Predicting sequences
• Single site analysis

Walkthroughs

• Web app: Lead optimization of monoclonal antibody to meet target product profile
• Python API: Quantitative decision making for library design

Structure prediction

Web app tutorials

• Using the Structure Prediction Tool

Python API tutorials

• Using ESMFold
• Using AlphaFold2

Walkthroughs

• Web app: Finding mutational hotspots and designing one-shot variant libraries

Analyzing your data

Web app tutorials

• Uploading your data
• Visualization

Walkthroughs

• Web app: Lead optimization of monoclonal antibody to meet target product profile

Navigating your completed work

Web app tutorials

• PoET history
• Navigating your projects

ML primer for the web app

Web app tutorials

• Prompt and prompt sampling methods
• Ensembling

Embeddings

Python API tutorials

• SVD embeddings
• Attention maps
• Basic inference endpoints
• Model metadata
• Logits

API reference

• Foundation models

Walkthroughs

• Web app: Visualizing antibody embeddings

Get familiar with our API

Python API tutorials

• PoET
• Property-regression-models
• Foundation models
• Structure prediction

Docs

• Python API