Demo datasets
Aliphatic amidase (AMIE_PSEAE)
This dataset is a single mutation site saturating dataset from Wrenbeck, Azouz, and Whitehead (2017) containing activity measurements for enzyme variants against three different substrates. The parent sequence is AMIE_PSEAE (UniProt identifier P11436).
6,819 entries with 3 properties. Download
Antibody heavy chain (14H)
This dataset contains binding affinity measurements to the target for a random mutagenesis library containing single, double, and triple mutants of an antibody heavy chain variable region from Li et al. (2022). Mutations were limited to CDRs 1, 2, and 3. Measurements are log base 10 of the binding Kd in nM.
7,476 entries with 1 property. Download
Antibody light chain (14L)
This dataset contains binding affinity measurements to the target for a random mutagenesis library containing single, double, and triple mutants of an antibody light chain variable region from Li et al. (2022). Mutations were limited to CDRs 1, 2, and 3. Measurements are log base 10 of the binding Kd in nM.
14,339 entries with 1 property. Download
Aminoglycoside 3'-phosphotransferase (KKA2_KLEPN)
This is a single mutation site saturating dataset from Melnikov et al. (2014). containing measurements of E. coli growth in the presence of six different antibiotics. This protein is a kinase that confers antibiotic resistance, hence, growth measures the activity of the kinase on these antibiotic substrates. The parent sequence is KKA2_KLEPN (UniProt identifier P00552)
5,279 entries with 6 properties. Download